冯茜

姓名：冯茜

出生年月：1991年8月

职称：副研究员

电子邮件：fengqiangrace@fjnu.edu.cn

通信地址：福建省福州市仓山区上三路8号福建师范大学仓山校区化学楼东504

教育背景：

• 2009.09-2013.06 华东理工大学 高分子材料与工程 工学学士

• 2013.08-2017.11 香港中文大学 生物医学工程 工学博士

工作经历：

• 2018.09-至今 福建师范大学 化学与材料学院 副研究员

研究方向：

• 新型水凝胶的设计与制备

• 水凝胶在组织工程与再生医学中的应用

• 导电水凝胶及可穿戴柔性医疗器件

在研课题：

• 国家自然科学基金青年项目：用于软骨及软骨下骨缺损修复的双层超分子水凝胶研究（批准号：31900963，2020-2022，25

• ）

• 福建省第五轮卫生教育联合攻关计划：二次注射成型水凝胶用于骨关节炎中组织缺损修复的关键技术研究（批准号：2019-WJ-22，2019-2022，35万）

发表文章：

• Feng, Q.; Xu, J.; Zhang, K.; Yao, H.; Zheng, N.; Zheng, L.; Wang, J.; Wei, K.; Xiao, X.; Qin, L.; *Bian, L. Dynamic and cell-infiltratable hydrogels as injectable carrier of therapeutic cells and drugs for treating challenging bone defects. ACS Central Science, 2019, 5: 440-450. (SCI一区，IF=12.837)

• +Xu, J.; +Feng, Q.; (+共同第一作者) Lin, S.; Yuan, W.; Li, R.; Li, J.; Wei, K.; Chen, X.; Zhang, K.; Yang, Y.; Wu, T.; Wang, B.; Zhu, M.; Guo, R.; Li, G.; *Bian, L. Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules. Biomaterials, 2019，210:51-61. (SCI一区，IF=10.273)

• +Kang, H.; +Kim, M.; +Feng, Q. (+共同第一作者); Lin, S,; Wei, K.; Li, R.; Choi, C. J.; Kim, T.; Li, G.; *Oh, J. M.; *Bian, L. Nanolayered hybrid mediated synergistic co-delivery of ligand and ligation activator for inducing differentiation and tissue healing. Biomaterials, 2017, 149: 12-28. (SCI一区，IF=10.273)

• Feng, Q.; Wei, K.; Zhang, K.; Yang B.; Tian F.; Wang, G.; *Bian, L. One-pot Solvent Exchange Preparation of Non-swellable, Thermoplastic, Stretchable, and Adhesive Supramolecular Hydrogels Based on Dual Synergistic Physical Crosslinking. NPG Asia Materials, 2017, 10: e455. (SCI一区，IF=8.052)

• Feng, Q.; Lin, S.; Zhang, K.; Dong, C.; Wu, T.; Huang, H.; Yan, X.; Zhang, L.; Li, G.; *Bian, L. Sulfated hyaluronic acid hydrogels with retarded degradation and enhanced growth factor retention promote hMSC chondrogenesis and articular cartilage integrity with reduced hypertrophy. Acta Biomaterialia, 2017, 53: 314-329. (SCI一区，IF=6.638)

• Feng, Q.; Wei, K.; Lin, S.; Xu, Z.; Sun, Y.; Shi, P.; Li, G.; *Bian, L. Mechanically resilient, bioadhesive, and injectable supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration. Biomaterials. 2016, 101: 217-28. (SCI一区，IF=10.273)

• +Zhu, M.; +Feng, Q. (+共同第一作者); *Bian, L. Differential effect of hypoxia on human mesenchymal stem cell chondrogenesis and hypertrophy in hyaluronic acid hydrogels. Acta Biomaterialia.2014, 10:1333-1340.(SCI一区，IF=6.386)

• Feng, Q.; Zhu, M.; Wei, K.; *Bian, L. Cell-mediated degradation regulates human mesenchymal stem Cell chondrogenesis and hypertrophy in MMP-sensitive hyaluronic acid hydrogels. PLoS ONE.2014, 9: e99587.(SCI三区，IF=2.806)

• Lin, S.; Lee, W. Y. W.; Feng, Q.; Xu, L.; Wang, B.; Man, G. C. W.; Chen, Y.; Jiang, X.; Bian, L.; Cui, L.; Wei, B.; *Li, G. Synergistic effects on mesencymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation. Stem Cell Research & Therapy, 2017, 8:221-229.

• Zhao, P.; Wei, K.; Feng, Q.; Chen, H.; Wong, S. H. D.; Chen, X.; *Bian, L. Mussel-mimetic hydrogels with defined cross-linkers achieved by controlled catechol dimerization exhibiting tough adhesion for wet biological tissues. Chemical Communications, 2017, 53:12000-12003.

• Zhang, K.; Lin, S.; Feng, Q.; Dong, C.; Yang, Y.; *Li, G.; *Bian, L. Bioactive nanocomposite hydrogels stabilized by self-assembled multivalent bisphosphonate-magnesium nanoparticles mediate sustained release of magnesium ion and promote in-situ bone regeneration. Acta Biomaterialia, 2017, 64:389-400.

• Wei, K.; Chen, X.; Li, R.; Feng, Q.; *Bian, L. Multivalent host-guest hydrogels as fatigue resistant 3D matrix for excessive mechanical stimulation of encapsulated cells. Chemistry of Materials, 2017,20: 8604-8610.

• Ouyang, X.; Zhang, K.; Wu, J.; Wong, S. H. D.; Feng, Q.; *Bian, L. A Optical -printing scale microscaffold arrays for 3D cell culture. Scientific Report, 2017, accepted.

• Zhang, K.; Feng, Q.; Xu, J.; Xu, X.; Yeung, K.W.K.; *Bian, L. Self-assembled injectable nanocomposite hydrogels stabilized by bisphosphonate-magnesium (Mg2+) coordination regulates the differentiation of encapsulated stem cells via dual crosslinking. Advanced Functional Materials, 2017, 27: 1701642-1701651.

• Xu, Y.; Wei, K.; Zhao, P.; Feng, Q.; Choi, C.; *Bian, L. Preserving the adhesion of catechol-conjugated hydrogels by thiourea-quinone coupling. Biomaterials Science. 2016, 12:1726-1730.

• Zhu, M.; Feng, Q.; Sun, Y.; Li, G.; *Bian, L. Effect of cartilaginous matrix components on the chondrogenesis and hypertrophy of mesenchymal stem cells in hyaluronic acid hydrogels. Journal of Biomedical Materials Research Part B. 2016.

• Wei, K.; Zhu, M.; Su, Y.; Xu, J.; Feng, Q.; Lin, S.; Wu, T.; Xu, J.; Tian, F.; Xia, J.; Li, G.; *Bian, L. Robust biopolymeric supramolecular “Host-Guest Macromer” hydrogels reinforced by in situ formed multivalent nanoclusters for cartilage regeneration. Macromolecules. 2016, 49: pp 866–875.

• Zhu, M.; Lin, S.; Sun, Y.; Feng, Q.; Li, G.; *Bian, L. Hydrogels functionalized with N-cadherin mimetic peptide enhance osteogenesis of hMSCs by emulating the osteogenic niche. Biomaterials. 2016, 77: 44–52.

• Yan, X.; Zhou, Q.; Yu, J.; Xu, T.; Deng, Y.; Tang, T,;Feng, Q.; Bian, L.; *Zhang, L. Magnetite nanostructured porous hollow helical microswimmers for targeted delivery. Advanced Functional Materials.2015, 25: 5333-5342.

• Jiang, H.; Zhu, Y.; Feng, Q.; Su, Y.; Yang, X.; *Li, C. Nitrogen and phosphorus dual-doped hierarchical porous carbon foams as efficient metal-free electrocatalysts for oxygen reduction reactions. Chem. Eur. J. 2014: 3106-3112.

授权专利：

• 于永生；冯茜；靶向Grb2蛋白的抗肿瘤共价多肽抑制剂及其制备方法和应用（中国专利: CN106589062A）

• Bian, L.; Feng, Q.; Wei, K.; Li, G.; Lin, S. Injectable and Bioadhesive Hydrogel（美国专利: US9889086；已授权）