姓名：郑永芳
性别：女
职称：副教授
通讯地址：福州市仓山区上三路8号福建师范大学化学与材料学院
邮编：350007
教育经历
2015/09-2020/07清华大学/中国科学院大学国家纳米科学中心（联合培养），化学，博士
导师：王琛研究员 杨延莲研究员 李艳梅教授
2011/09-2015/-07兰州大学，化学（基地班），学士
科研与学术工作经历
2020/08-至今 福建师范大学 化学与材料学院
研究方向
主要从事纳米酶材料的设计合成及其在抗菌、传感和环境修复等领域的应用研究。聚焦于构建具有多酶活性、智能响应性或极端环境耐受性等特点的功能纳米酶体系。
科研项目
1. 国家自然科学基金青年科学基金，多肽组装中反常规手性传递模式的分子机制及生物活性研究（22307018），2014.01-2026.12，30万，主持，在研
2．福建省自然科学基金计划项目,多肽组装中新的手性传递模式的普适性研究（2025J01631），2025. 09-2028. 08，9万，主持，在研
3．福建省自然科学基金计划项目，线性/环状多聚苯丙氨酸自组装纳米结构中手性效应的单分子水平研究（2021J05033），2021. 11. 01-2024. 11. 01，8万，主持，已结题
4. 福建省教育厅中青年教师教育科研项目，手性对多肽组装结构的调控作用（JAT200087），2021. 01. 01—2022. 12. 31，1万元，主持，已结题
教学情况
本科生课程：《有机化学》、《无机化学实验》、《分析化学实验》
论文著作
[1].Chen, Yuyuan; Tian, Shuli; Zhu, Xinyu; Huang, Shuijing; Pang, Yuxuan; Zhuang, Chaojie; Zheng, Yongfang*; Zhu, Hu*, Ph-Switchable Dual-Enzyme Mimicry: Adenine-Cu Hybrid Nanoparticle with Haloperoxidase/Peroxidase Activities for Antibacterial and H₂O₂-Sensing Applications. Chem Eng J 2026, 530, 173374.
[2].Zheng, Yongfang#; Feng, Lisha#; Chen, Yuyuan; Zhu, Xinyu; Tian, Shuli; Ye, Jianbin; Zhu, Hu*, Cold-Adaptive Haloperoxidase-Mimicking Copper-Dipeptide Hybrid Nanoparticle for Antibiofilm Formation. Small 2025, 21 (30), 2502509
[3].Zheng, Y. F*#.; Zhu, X. Y. #; Jiang, M. Y.; Cao, F. F*.; You, Q*.; Chen, X. Y*., Development and Applications of D-Amino Acid Derivatives-Based Metabolic Labeling of Bacterial Peptidoglycan. Angew. Chem. Int. Ed. 2024, 63 (17), e202319400.
[4].Zheng, Y. F.#; Chen, S. X.#; Mao, K. J.; Zhu, H*., Enantiomeric Peptides Self-Assembling into Fibrils with the Same Handedness. Chem. Commun. 2024, 60 (97), 14475-14478.
[5].Zheng, Yongfang#; Jiang, Mingyi#; Zhu, Xinyu; Chen, Yuyuan; Feng, Lisha; Zhu, Hu*, Metabolic Labeling-Mediated Visualization, Capture, and Inactivation of Gram-Positive Bacteria Via Biotin-Streptavidin Interactions. Chem. Commun. 2024, 60 (27), 3697-3700.
[6].Zheng, Yong Fang#; Chen, Shi# Xian; Mao, Ke Jing; Zhu, Xin Yu; Jiang, Ming Yi; Wu, Chang Jer; Lu, Jian Ren*; Zhu, Hu*, De Novo-Designed Antimicrobial Peptides with Broad-Spectrum Antimicrobial Potency and Rapid Wound Disinfection. Colloid Surface A 2023, 667, 131355.
[7].Zheng, Yongfang#*; Mao, Kejing#; Chen, Shixian; Zhu, Xinyu; Jiang, Mingyi; Wu, Chang Jer; Zhu, Hu*, Identification of Heterochirality-Mediated Stereochemical Interactions in Peptide Architectures. Colloids and surfaces. B, Biointerfaces 2023, 224, 113200.
[8].Zheng, Yongfang*; Luo, Wendi; Yu, Lanlan; Chen, Shixian; Mao, Kejing; Fang, Qiaojun; Yang, Yanlian; Wang, Chen; Zhu, Hu*; Tu, Bin*, Heterochirality-Mediated Cross-Strand Nested Hydrophobic Interaction Effects Manifested in Surface-Bound Peptide Assembly Structures. J. Phys. Chem. B. 2022, 126 (3), 723-733.
[9].Zheng, Yong Fang; Fang, Xiao Cui; Yang, Yan Lian*; Wang, Chen*, Peptide-Directed Delivery of Drug-Loaded Nanocarriers Targeting Cd36 Overexpressing Cells. Colloid Surface A 2021, 610.
[10]. Zheng, Yongfang*; Mao, Kejing; Chen, Shixian; Zhu, Hu*, Chirality Effects in Peptide Assembly Structures. Front. Bioeng. Biotech. 2021, 9 (517), 703004.
[11].Zheng, Yong Fang; Yu, Lan Lan; Zou, Yi Min; Yang, Yan Lian*; Wang, Chen*, Steric Dependence of Chirality Effect in Surface-Mediated Peptide Assemblies Identified with Scanning Tunneling Microscopy. Nano. Lett. 2019, 5403-5409.
[12]. Zheng, Yong Fang; Xu, Meng; Yu, Lan Lan; Qu, Fu Yang; Lin, Yu Chen; Xu, Jing; Zou, Yi Min; Yang, Yan Lian*; Wang, Chen*, Identifying Terminal Assembly Propensity of Amyloidal Peptides by Scanning Tunneling Microscopy. Chemphyschem 2019, 20 (1), 103-107.
